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Antibi�ticos: cerca de 700 mil pessoas morrem anualmente v�timas da?? resist�ncia antimicrobiana �
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Cientistas anunciaram nesta semana a descoberta de uma nova classe estrutural de antibi�ticos. O?? artigo com a descobertas foi publicado na revista cient�fica "Nature" e foi apresentado como um avan�o significativo no estudo dessas?? drogas

profundo (deep learning) para prever atividades de toxicidade, examinando virtualmente mais de 12 milh�es de compostos candidatos.

Esta abordagem inovadora resultou?? ent�o na identifica��o de uma nova classe de antibi�ticos com potente atividade contra pat�genos resistentes a m�ltiplos medicamentos.Na pesquisa, os?? cientistas investigaram a atividade antibacteriana dos compostos os testando contra um tipo de bact�ria, o Staphylococcus aureus resistente � meticilina?? (ou SARM).

Uma inova��o-chave do estudo

foi a capacidade de compreender as informa��es usadas pelo modelo para fazer suas previs�es de pot�ncia?? antibi�tica. Para isso, os pesquisadores desenvolveram um algoritmo de busca com o intuito de revelar n�o apenas uma estimativa da?? atividade antimicrobiana de cada mol�cula, mas tamb�m uma previs�o das subestruturas da mol�cula que provavelmente eram respons�veis por essa atividade.

Uso?? desenfreado de antibi�ticos na pandemia pode levar a 'apag�o' contra bact�rias resistentes

Posteriormente, tr�s modelos de modelos para se prever a?? a��o antimicrobicida

adicionais de deep learning foram treinados para prever a toxicidade desses compostos para diferentes tipos de c�lulas humanas. Combinando?? essas informa��es com as previs�es de atividade antimicrobiana, os pesquisadores identificaram compostos capazes de matar microrganismos com efeitos adversos m�nimos?? no corpo humano.

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"adi��o de antimicrobianos para o nosso sistema imunol�gico."

insight aqui foi que poder�amos ver?? o que os modelos estavam aprendendo para fazer suas previs�es de que certas mol�culas seriam eficazes como antibi�ticos", disse James?? Collins, professor de Engenharia M�dica e Ci�ncia no Instituto de Tecnologia de Massachusetts (MIT) e um dos autores do estudo,?? em um comunicado.

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